Interim Analysis and Multiplicity: O'Brien-Fleming and Bonferroni
This lesson is part of the course
In this lesson
You run the planned interim look at half the data against a given O'Brien-Fleming boundary, convert the boundary into a nominal α, and adjust four secondary endpoints with Bonferroni.
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Lessons in this course
- Sample Size: Two Proportions and Two Means with NORM.S.INV Locked
- Power for a Given Sample Size and a Power Curve Locked
- Block Randomisation: Allocating Patients and Checking Balance Locked
- The Baseline Table: Means, SDs and % by Arm Locked
- Primary Endpoint: Difference in Proportions, 95% CI and p-Value Locked
- Number Needed to Treat (NNT), Its CI and the Number Needed to Harm Locked
- Kaplan-Meier Survival Table by Hand + a Step Chart Locked
- Interim Analysis and Multiplicity: O'Brien-Fleming and Bonferroni Locked